A Systematic Review and Meta-Analysis on the Effects of Transcranial Direct Current Stimulation in Depressive Episodes

Razza et al, 2020. Depression & Anxiety.

  • A meta-analysis of randomised, sham-controlled clinical trials (RCTs).
  • Active Transcranial direct current stimulation (tDCS) vs. sham-tDCS for acute depression.
  • Based on 23 RCTs and a total of 1,092 participants.
  • tDCS was superior to sham-tDCS in terms of endpoint depression scores, response rate (33.3% vs. 16.56%), and remission rate (19.12% vs. 9.78%).


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